Abstract
BackgroundCarbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CDs as promising drug for psoriasis treatment. The as-prepared CDs using Phellodendri Chinensis Cortex (PCC) as sole precursor were characterized by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS).ResultsResults displayed that fluorescence (Quantum yield = 5.63%) and nontoxic PCC-based CDs (PCC-CDs) with abundant chemical groups exhibited solubility and tiny sizes at average of (1.93 ± 0.53) nm, which may be beneficial for its inherent biological activity. Moreover, by using the typical imiquimod (IMQ)-induced psoriasis-like skin mouse model, we firstly demonstrated the pronounced anti-psoriasis activity of as-prepared PCC-CDs on ameliorating the appearance, psoriasis area and severity index (PASI) scores as well as histopathological morphology of both back skin tissues and right ears in IMQ-induced mouse. Further potential mechanisms behind the anti-psoriasis activities may be related to suppress M1 polarization and relatively promote M2 polarization of macrophage both in vitro and in vivo.ConclusionThese results suggested that PCC-CDs have potential to be an anti-psoriasis candidate for clinical applications to treat psoriasis, which not only provided an evidence for further broadening the biological application of CDs, but also provided a potential hope for application nanodrugs to treat thorny diseases.Graphic
Highlights
Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases
The Characterization of Phellodendri Chinensis Cortex (PCC)‐CDs Transmission electron microscope (TEM) image (Fig. 2a) exhibited PCC-based CDs (PCC-CDs) prepared at 400 °C possessed monodispersed and quasi-spherical structure with size diameters ranging from 0.5 nm to 3.6 nm (Fig. 2b)
By using the classic IMQ-induced psoriasis-like skin model, we preliminarily proved the protective effects of PCC-CDs on elevated psoriasis area and severity index (PASI) scores and severe appearance in dorsal skin tissues and right ears of animals treated with IMQ
Summary
Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. Excessive evidences reported CDs derived different precursors [9,10,11] or preparing conditions (preparing temperature, time, etc) [12,13,14] showed different properties, mainly performed on the aspects of size, charge and chemical groups These differences in properties have been demonstrated to be closely connected with the bioactivities of CDs, which further provided a rational explanation for the fact that CDs currently found possessed different activities including anti-inflammation [15], antioxidant [16], anticonception [17], anti-bacteria [18, 19] and hemostasis [20]. The undiscovered and study-worthy potentials of CDs for controlling or treating other diseases such as psoriasis become the focus of current research, which deserved to be conducted
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