Abstract

Even though we live in an age of modern technology and innovation, infectious diseases such as Malaria are among the biggest health challenges worldwide. The main drawbacks of conventional Malaria disease chemotherapy are developing multidrug resistance and targeting non-specific parasites, resulting in high dose requirements and subsequently intolerable toxicity. To combat this trend, research in nanotechnology and nanomedicine has begun to develop new biochemicals capable of incorporating drugs, contributing to Malaria disease treatment through diagnosis, control, and targeted delivery. Nanotechnology has emerged as a powerful tool to develop safe, cheap, and highly effective antiMalaria drug therapies. Metal nanoparticles fabricated via green and eco-friendly approaches have shown potential against mosquito-borne diseases. The plant extracts and extract-mediated nanoparticles have demonstrated significant bio-efficacy to combat Malaria vectors and offer a promising strategy for treating Malaria disease. Also, nano-bio sensors potential for diagnosing Malaria disease has become greater than before since they can be affordable, sensitive, and reliable applications that could substitute the conventional detection techniques in the future. Biosensors have improved the scope for Malaria diagnosis with novel biorecognition and transducer components, which allow the construction of affordable biosensor platforms with improved characteristics. Herein, we present recent studies on the plant extract-mediated fabrication of green nanoparticles and their effectiveness in treating Malaria-infected patients.

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