Abstract
Cymbopogon citratus is grown globally for therapeutic application is utilized to synthesize colloidal silver nanoparticles (CcAgNps). CcAgNps are characterized by biophysical methods and are tested against CTXM-15 expressing pathogenic Escherichia coli strains. MIC, MBC and biofilm assays are performed at different concentrations of nanoparticles. The expression of CTXM-15 gene responsible for antibiotic resistance is analyzed by polymerase chain reaction to identify the role of CTXM-15 in pathogenesis. CcAgNps show better antibacterial and anti-biofilm activity when compared to antibiotics. This study suggests that CcAgNps are the potential antibiotic resistance breakers to control pathogenic E. coli and can be utilized as alternatives to antibiotics.
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