Abstract
Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan–ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan–ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan–ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer–drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.
Highlights
With the improvement of life quality, the irregular lifestyle of people results in the development of chronic diseases such as osteoarthritis, diabetes, hypertension, low back pain, neck pain, Parkinson’s disease, and rheumatoid arthritis (Chiang et al, 2021)
The thermal properties of ibuprofen, chitosan, and chitosan–ibuprofen aerogels were determined via differential scanning calorimetry (DSC, DSC 25) and thermogravimetric analysis (TGA, TG209 F3). 5–8 mg of the sample was placed in an aluminum pan and heated at temperatures between 0°C and 200°C at a heating rate of 20°C/min under nitrogen with a flow of 20 ml/min
Chitosan was dissolved in 10 ml of 1% glacial acetic acid at 45°C, and 1 g of ibuprofen was solubilized in 10 ml of 0.1M NaOH solution
Summary
With the improvement of life quality, the irregular lifestyle of people results in the development of chronic diseases such as osteoarthritis, diabetes, hypertension, low back pain, neck pain, Parkinson’s disease, and rheumatoid arthritis (Chiang et al, 2021). It is a potential polymer to be used for preparing transdermal drug delivery systems (TDDSs) due to its abundant natural occurrence, biocompatibility, good mechanical properties, bioadhesive properties, biodegradability, low toxicity, and enhancer absorption effect (El Menshawe et al, 2020; CastillaCasadiego et al, 2021; Morad et al, 2021; Takeuchi et al, 2021; Talib et al, 2021) Among these chitosan-based TDDSs, chitosan–ibuprofen aerogel has attracted more and more attention because of its excellent swelling ratio and ease of preparation, and in addition, it can open the tight junction in chitosan–ibuprofen to improve the drug penetration through mucosal tissues. This work may be a promising method to design a polymer–drug transdermal delivery system for controlling the release of ibuprofen and other poorly water-soluble drugs
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