Abstract
This article reports an alternative method for preparing nitrones using a tetrahedral capsule as a nanoreactor in water. Using the hydrophobic cavity of the capsule allowed us to reduce the reaction times and easily separate the nitrones from the reaction mixture, obtaining reaction yields equal or comparable to those obtained with the methods already reported. Furthermore, at the basis of this methodology, there is an eco-friendly approach carried out that can certainly be extended to other synthesis methods for the preparation of other substrates by exploiting various types of macrocyclic hosts, suitably designed and widely used in supramolecular chemistry.
Highlights
One of the purposes of a supramolecular chemist is to mimic biologicalSeparation of Nitrones in Water 1.where
Capsule 1 was synthesized according to the method reported in the literature [12], employing 2,3-dimethoxybenzoic acid and naphthalene-1,5-diamine as building blocks for the ligand synthesis and gallium(III) acetylacetonate in water for the assembly; all details are reported in Scheme S1
The traditional methodologies for synthesizing these substrates foresee the use of chromatographic separation [11]
Summary
To mimic the work wide range of supramolecular systems that try to mimic the work carried out by enzymes enzymes have been reported in the literature, and various types of building bl have been reported in the literature, and various types of building blocks are being studied, being studied, producing a wide range of cavities that can be used for catalysis [1 producing a wide range of cavities that can be used for catalysis [1–7].
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