Abstract
A comparison of the effectiveness of two synthetic methods was done for a green chemistry method using an ionic liquid-based solvent relative to a conventional method using organic solvents for the N-alkylation of indole. The green method used potassium hydroxide in the ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, followed by addition of the alkyl halide. The conventional method used sodium hydride in dimethylformamide. Possible advantages of the green method would be the use of a non-volatile solvent, the possibility of recycling the solvent, and the use of a less reactive base. However, its reaction yield was lower than for the conventional method, the reagent expense was higher, and recycling and reuse of the ionic solvent require considerable amounts of conventional solvent to clean it up sufficiently for reuse. On a laboratory scale, the ionic liquid method yielded neither a “green” nor an efficiency advantage. It is possible that with optimization on an industrial scale involving solvent reclamation that the green method could realize its promise. KEYWORDS: Green Chemistry; Sustainable Chemistry; Ionic Liquids; N-alkylation; Indole; Solvent Recycling; Organic Chemistry; 1-Butyl-3-methylimidazolium Tetrafluoroborate; Synthesis
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