Abstract
Methylene blue is a solid; its water solution is deep blue. It has been described as “the first fully synthetic drugused in medicine.” Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. It is on the WorldHealth Organization’s List of Essential Medicines. It has been increasingly used in the management of refractorydistributive shock. A 16 years old boy following liver transplantation developed septicemia. During autopsywhen dissecting brain, grey matter showed colour change from grey to green-blue in a few seconds. Green-bluediscolouration of brain was an incidental finding in this case and when back referred it was found that youngmale developed acute liver failure and had undergone liver transplantation. Following transplant rejection hedeveloped refractory hypotension, septic shock and multiple organ dysfunction syndrome. So in that criticalcondition methylene blue was given which is an effective drug for refractory shock.
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