Abstract
Green Approaches in Sample Preparation for the Estimation of Atenolol, Aspirin, Atorvastatin Calcium and Losartan Potassium in Bulk and its Pharmaceutical Dosage Form Prior to Chromatographic Technique
Highlights
Atorvastatin calcium (AC) is chemically described as [R-(R_,R_)]-2-(4- fluorophenyl)-dihydroxy-5-(1-methylethyl)3-phenyl-4-[(phenylamino) carbonyl]-1Hpyrrole-1-heptanoic acid calcium salt trihydrate
quality target product profile (QTPP) determines the quality of the product, which helps us to define targeted responses to be optimized in the life cycle of the product
Based on the critical quality attributes (CQA), Analytical target profile (ATP) was designed with accuracy, precision, specificity, linearity were selected as method performance characteristics for assay (Qparameter)
Summary
Atorvastatin calcium (AC) is chemically described as [R-(R_,R_)]-2-(4- fluorophenyl)-dihydroxy-5-(1-methylethyl)3-phenyl-4-[(phenylamino) carbonyl]-1Hpyrrole-1-heptanoic acid calcium salt trihydrate. Aspirin (AS) f2-acetyloxy-1-benzoic acid has an anti-platelet effect at the dose included in the selected combined dosage form [1,2] Figure 1 a, b, c, and d represented the structure of AS, AT, AC and LP.
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