Abstract
17Sep 2016 GREEN APPROACH TOWARDS SYNTHESIS OF 3-SUBSTITUTED-5-CARBONYLMETYL-1,2,4-OXADIAZOLES WITHOUT ANY SOLVENT AND CATALYST VIA TRANSAMIDOXIMATION. G. B. Dharma Rao and Ravi Gujjula. Discovery Centre, Process Technology Development Division, Defence R. & D. Establishment, Jhansi Road, Gwalior – 474002 (M.P), India. Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad - 501301 (TS), India.
Highlights
Which further experience intramolecular cyclization followed by dehydration at 110°C
Simple, environmentally benign, cost-effective and Received: 12 July 2016 Final Accepted: 19 August 2016 Published: September 2016 expeditious etiquette for the construction of biologically momentous 3-substituted-5-carbonylmetyl-1,2,4-oxadiazole derivatives in one-pot has been developed by the reaction of methyl β-ketoesters with an assortment of amidoximes via transamidoximation transformation, Key words:1,2,4-Oxadiazoles, Methyl β-Ketoester, Amidoxime, trans-Amidoximation, Green Chemistry
Β-Ketoesters serves as an reliable synthon which were employed in synthesis of polymers, drugs, biologically dynamic compounds and utilized as building blocks in the construction of complex natural products.[28] βKetoesters have demonstrated to be a advanced synthon essentially for the reason that the occurrence of both electrophilic in addition to nucleophilic centers. β-Ketoesters underwent to acetylketene intermediate formed by the abolition of alcohol i.e removal of alkoxy moiety of β-ketoester and hydrogen adjacent to it under thermal conditions
Summary
GREEN APPROACH TOWARDS SYNTHESIS OF 3-SUBSTITUTED-5-CARBONYLMETYL-1,2,4OXADIAZOLES WITHOUT ANY SOLVENT AND CATALYST VIA TRANSAMIDOXIMATION. Dharma Rao*,1,2 and Ravi Gujjula[2]. 1. Discovery Centre, Process Technology Development Division, Defence R. Establishment, Jhansi Road, Gwalior – 474002 (M.P), India. 2. Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad - 501301 (TS), India
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