Abstract
Investigation on the biomedical applications of flower-like Zinc Oxide (ZnO) nanostructures (NSs) synthesized by using aqueous extract of Oryza punctata (red rice) is reported for the first time. For the sustainable preparation of ZnO NSs, the precursors zinc nitrate and the rice extract act as the bio-template material. The optical energy bandgap value for the ZnO NSs was found to be 3.29 eV. The flower-like morphology of the ZnO NSs was confirmed by field emission scanning electron microscopy analysis. The ZnO NSs showed the potential cytotoxicity activity against MCF-7 cell line and antibacterial properties. Significant antioxidant activity was studied by the bio-prepared ZnO NSs against scavenging of DPPH (di(phenyl)-(2,4,6-trinitrophenyl) iminoazanium) free radicals. The flower-like ZnO NSs showed a significant anti-arthritic activity with a maximum inhibition of protein denaturation (78.94 ± 1.62%) and membrane protective activity (81.12 ± 1.25%) at a dose of 0.5 mg/mL concentration.
Highlights
In recent trends, Nanomaterials (NMs) with size and structural dependent characteristics behavior are the essential for the various applications [1]
The goal of our research is to develop flower-like Zinc Oxide (ZnO) NSs using the bio-template approach in order to improve the biological applications
The results demonstrate that, reduction in size of the viable cells happened when increase the concentration of ZnO NSs synthesized from Oryza punctata rice extract
Summary
Nanomaterials (NMs) with size and structural dependent characteristics behavior are the essential for the various applications [1]. An effort has been made to synthesis flower like ZnO NSs using Oryza punctata (red rice) rice extract and succeeded. Polymeric chains form in the carbohydrate component via glucose (starch) units, which are separated in linear amylase and amylopectin [33, 23] These features are crucial structural factors in the development of novel functional NMs [33].Besides, Oryza punctata contains bioactive compounds comprising phenolic antioxidants that have the capability of reducing the risk of diseases such as, coronary heart disease, preventing platelet aggregation, reducing the risk of cancer and inhibiting oxidative damage of lipids and low-density lipoproteins. Proanthocyanidins accumulation in rice bran gives the rice red pigment Phytoconstituents such as peptides and phenolic compounds exhibit antioxidant and anticancer properties [34]. Finocchiaro et al [35] conveyed that proanthocyanidins of Oryzapunctata show potent antioxidant capacity
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