Green and Efficient Iron‐Catalysed Synthesis of Polyfunctionalized Benzofuran‐4(5H)‐one Derivatives via Cross‐Dehydrogenative Coupling

Abstract

AbstractAn efficient and facile protocol for the synthesis of a multi‐functional 6,7‐dihydrobenzofuran‐4(5H)‐ones and their derivatives using iron salt in the presence of air via reactions of readily available dimedone, acetophenone and isocyanide as starting materials. This approach illustrate operational simplicity, offering a modified and expedient methodology for the direct construction of synthetically useful benzofuran derivatives in good to excellent yields. Benzofuran derivatives have many biological importance. This documented strategy, provide a cost effective and environmentally benign alternative to the other existing method.