Green Analytical UV-VIS Spectrophotometric Method Development of Valsartan by using Hydrotropic agent

Abstract

The aim of the present research was to increase the solubility of valsartan in water by hydrotropic solubilisation. Hydrotopes are surface active, highly water soluble organic salt, which imparts solubility to insoluble or sparingly soluble organic compounds in water, which is when present at higher concentration. An analytical method was developed for the estimation of valsartan by UV-VIS spectrophotometry. Solvent 1% w/v sodium acetate solution was utilized and 247.2nm was the wavelength for measurement of absorbance. Effect of input variables on spectrum characteristics were studied for selection of critical parameters and developed method was validated as per ICH Q 2 R1 regulatory guidelines. Linearity of the drugs was ascertained over the conc range 4-48mcg/ml (microgram/ml). The accuracy was found within acceptable limit with nominal conc102.68 – 105.10 %; and the precision study was shown acceptable data as %SD varied from 1.88573 to 3.97617. The stability of the method was studied by minor variation in the wavelength, scan speed and acid, alkali and peroxide stress degradation study. The developed method is rigid, robust and efficient for the estimation of VST from the dosage form. The effort was made to develop green or eco-friendly analytical method utilising hydrotropic solvent for water insoluble drug valsartan.