Abstract
Background Recent data have shown that in the early stages of Alzheimer’s disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. Methods Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging, were analyzed retrospectively in 72 patients with early and late onset sporadic AD. Results All types of ischemic lesions occurred more frequently in the AD patients than in the controls. Analysis of subgroups of early and late onset AD patients diagnosed by magnetic resonance imaging showed a more frequent occurrence of subcoritcal lesions in severely demented patients with early onset AD. Conclusions The non-stroke subcortical ischemic lesions occurring more frequently in our AD patients might be recognized as the concomitant vascular pathology that characterizes severely demented patients with early onset sporadic AD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
