Gray Matter Correlates of Finger Gnosis in Children: A VBM Study

Abstract

Accumulating evidence relates finger gnosis (also called finger sense or finger gnosia), the ability to identify and individuate fingers, to cognitive processing, particularly numerical cognition. Multiple studies have shown that finger gnosis scores correlate with or predict numerical skills in children. Neuropsychological cases as well as magnetic stimulation studies have also shown that finger agnosia (defects in finger gnosis) often co-occurs with cognitive impairments, including agraphia and acalculia. However, our knowledge of the structural and functional correlates, and the development of finger gnosis is limited. To expand our understanding of structural brain features that are associated with finger gnosis, we conducted a voxel-based morphometry study with 42 seven- to 10-year-old children, where we investigated the correlation between finger gnosis scores and whole-brain gray matter volume (GMV). Correlations between finger gnosis and GMV were found in a set of frontoparietal, striatal, and cerebellar areas. We also found sex differences in how GMV is associated with finger gnosis. While females showed a more distributed and extensive set of frontal and parietal clusters, males showed two striatal clusters. This study provides the first findings on structural brain features that correlate with finger gnosis.