Abstract
Introduction. The study is of relevance due to the need to expand the theoretical developments in the field of spatial economics within the regional system in order to form adequate and flexible measures to stimulate and support the subjects of the intraregional environment. With regard to the state authorities’ growing interest in the tendencies of spatial development of territories, a careful analysis of the full diversity of processes and connections that take place within individual regions is necessary. The purpose of the study is to identify and analyze these processes. Materials and Methods. The information and empirical base of the study included statistical data presented on the official website of the regional Department of Statistics in the Stavropol Territory and its municipal units. Fundamental methods of scientific knowledge were employed, the gravitational model was applied, and the tools of correlation and regression analysis were used to test hypotheses and calculated conclusions. Results. For the first time, analytical data were obtained on the level, strength and direction of the spatial gravitation between the center and the peripheral territories in an agro-industrial region – the Stavropol Territory. The gravitational model adapted for studying the spatial processes of interaction of the ‘center–periphery’ system was for the first time tested in the conditions of an agro-industrial region. On the basis of the theory of gravitational environments, conclusions were drawn about the presence of specific processes in the region in the form of establishment of ‘the second-order’ gravitation centers, which are ‘beacons’ for the periphery due to a higher level of socio-economic development and general territorial remoteness from the main regional center. Discussion and Conclusion. The implementation of the presented diagnostic approach made it possible to put forward a number of hypotheses about the presence and specificity of the spatial connections between the objects of the regional ‘center–periphery’ system. The force of gravitation, the direction and type of the spatial drift can have a direct impact on the level of socio-economic development of the periphery. The specified factors affect the overall ‘survival’ potential of the peripheral territories. The results of the study are of practical importance and can be used as the empirical justification for program projects aimed at stimulating development of regions.
Highlights
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Summary
Ensuring the safety of medicines is the basis for the existence and functioning of any pharmacovigilance system as a type of activity aimed at obtaining and processing information about the undesirable consequences of the use of medicines. Исследование особенностей функционирования систем фармаконадзора в странах – участницах международной программы мониторинга безопасности лекарственных средств позволило выделить несколько типов организации сбора информации о нежелательных реакциях лекарственных средств: централизованный, децентрализованный и смешанный. Такой тип организации системы фармаконадзора представлен, например, в США, где все контролирующие функции в сфере оборота лекарственных средств возложены на Управление по санитарному надзору за качеством пищевых продуктов и медикаментов (Food and Drug Administration, FDA), которое является одним из федеральных исполнительных департаментов Министерства здравоохранения и социальных служб США. Основой функционирования централизованной системы фармаконадзора в США является программа MedWatch, позволяющая специалистам здравоохранения, пациентам и потребителям предоставлять в FDA информацию о нежелательных реакциях, возникающих при применении рецептурных и безрецептурных лекарственных средств, особенностях применения биологических препаратов, специальных пищевых продуктов (например, детских питательных смесей), а также о медицинских приборах и косметологических средствах. The centralized type of organization of the pharmacovigilance system exemplified by the U.S Food and Drug Administration (FDA)
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