Abstract
We demonstrate intensity-based optical coherence tomography (OCT) angiography using the squared difference of two sequential frames with bulk-tissue-motion (BTM) correction. This motion correction was performed by minimization of the sum of the pixel values using axial- and lateral-pixel-shifted structural OCT images. We extract the BTM-corrected image from a total of 25 calculated OCT angiographic images. Image processing was accelerated by a graphics processing unit (GPU) with many stream processors to optimize the parallel processing procedure. The GPU processing rate was faster than that of a line scan camera (46.9 kHz). Our OCT system provides the means of displaying structural OCT images and BTM-corrected OCT angiographic images in real time.
Highlights
Optical coherence tomography (OCT) is a noncontact, noninvasive imaging modality that can provide high-resolution, depthresolved imaging of internal microstructures within the tissue.[1]
Structural OCT and OCT angiography can be obtained in real time
We demonstrated graphics processing unit (GPU)-accelerated IB-OCT angiography by calculating the squared difference between two sequential frames with the simple BTM correction on the order of a pixel
Summary
Optical coherence tomography (OCT) is a noncontact, noninvasive imaging modality that can provide high-resolution, depthresolved imaging of internal microstructures within the tissue.[1]. Recent technological advances in OCT-based flow imaging techniques can be grouped into two categories: Doppler OCT and OCT angiography. Phase-resolved Doppler OCT uses the phase difference between adjacent A-lines to extract the Doppler frequency shift and quantitative information, such as blood flow speed and direction.[4,5,6,7,8] The power of Doppler shift images and phase variance images can be used to construct OCT angiograms for vasculature visualization.[9,10] For bulk-tissuemotion (BTM) on the order of a wavelength, which is much smaller than the axial resolution, the effect of motion appears as a phase shift. A number of methods for bulk-phase correction have been proposed.[7,10]
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