Abstract
The constantly-evolving field of biosensors has attracted the focus of attention of the biomedical field due to their outstanding capacities for performing real-time in-vivo non-invasive studies for biomarkers detection and quantification. Furthermore, the field of electrochemical biosensors has been of increase interest given its potential to easily convert biological phenomena into an electrical measurable signal. By using supercapacitors as a potential technique for developing biosensors, we have been able to target specific human serum proteins, in this case, D-Dimer. By utilizing graphene oxide as a base nanocomposite for antibody fixation, we have been able to immuno-functionalize an electrode with monoclonal antibodies and target this biomarker which has been identified as a target molecule for diagnosis of venous thromboembolism-related conditions. Nanocomposite characterization and electrode immuno-functionalization was studied with Fourier transform infrared (FTIR), Raman spectroscopy (RS), X-ray diffraction (XRD), and thermal gravimetric analysis (TGA). Finally, antibody-antigen interactions for D-Dimer detection were studied with cyclic voltammetry (CV) in a 3-electrode configuration.
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