Graphene-based nanomaterials combined with early exercise rehabilitation training in the treatment of patients with infectious bone defects

Abstract

With the rapid development of industry and transportation, the incidence of open fractures caused by high-energy injuries has increased year by year, and bone infections are prone to occur after open fractures. According to the needs for the treatment of open fracture infections and bone defects, graphene in carbon nanomaterials has many advantages as bone graft materials. The purpose of this study was to make use of the unique physical and chemical properties of carbon nanomaterials to prepare a three-dimensional composite scaffold with good bone properties and some antibacterial properties, and carry antibiotics for the treatment of infection and bone defect after open fractures. The results show that the prepared reduced graphene oxide (RGO)-nHA composite scaffold has an interconnected three-dimensional porous structure, and the bone formation performance is enhanced when nHA is incorporated, which can promote cell growth and bone regeneration; vancomycin is loaded on this composite scaffold later, due to the bonding with graphene, the drug can be released relatively quickly in the initial stage, and then the drug is released slowly. The combination of the drug's sustained release characteristics and the inherent antibacterial activity of graphene can ensure rapid treatment of infections, and provide lasting inhibition of bacteria. In vivo experiments have also shown that the drug-loading system can effectively treat infectious bone defects.