Abstract
DNA detection with high sensitivity and specificity has tremendous potential as molecular diagnostic agents. Graphene and graphene-based nanomaterials, such as graphene nanopore, graphene nanoribbon, graphene oxide, and reduced graphene oxide, graphene-nanoparticle composites, were demonstrated to have unique properties, which have attracted increasing interest towards the application of DNA detection with improved performance. This article comprehensively reviews the most recent trends in DNA detection based on graphene and graphene-related nanomaterials. Based on the current understanding, this review attempts to identify the future directions in which the field is likely to thrive, and stimulate more significant research in this subject.
Highlights
DNA is the molecule that encodes genetic instructions
By aiming at speeding up the realization of quick and accurate DNA detections in the market, we reviewed recent progresses and achievements in the topic of DNA detection using graphene and graphene-based nanomaterials
Due to this electronic n-doping phenomenon, Dong et al [123] found that the shift in Vg.min of the probe DNA immobilized graphene transistors is sensitive to addition of complementary DNAs (cDNAs) with a concentration as low as 0.01 nM, which indicated the high sensitivity of their device for the DNA detection
Summary
DNA is the molecule that encodes genetic instructions. As the blueprint of life, DNA detection has received significant attention in recent years due to its promising applications in disease diagnosis and treatment, forensic analysis, food safety evaluation, environmental monitoring, and so on. In the field of DNA detection, the application of graphene research hotspot in recent years. In the field of DNA detection, the application of graphene could thethe sensitivity and and selectivity of theof testing technique. The carrier concentration and mobility, low charge-transfer resistance, good biocompatibility and easy high charge carrier concentration and mobility, low charge-transfer resistance, good biocompatibility biological and chemical [28], demonstrate graphene to be a promising in and easy biological andfunctionalization chemical functionalization [28], demonstrate graphene to be amaterial promising the development of rapid, accurate, sensitive and portable detection techniques. Material in the development of rapid, accurate, sensitive and portable DNA detection techniques. There are a lot of reports demonstrating demonstrating the the adaptation of graphene and graphene based nanomaterials for the applications of detection.
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