Abstract
A novel sensing platform for sensitive detection of copper(ii) ions (Cu2+) in living cells and body fluids was developed by taking advantage of the excellent fluorescence quenching ability of graphdiyne (GDY) and the high specificity of click chemistry for the first time.
Highlights
A novel sensing platform for sensitive detection of copper(II) ions (Cu2+) in living cells and body fluids was developed by taking advantage of the excellent fluorescence quenching ability of graphdiyne (GDY) and the high specificity of click chemistry for the first time
The N3 groups of N3-double-stranded DNA (dsDNA)-6-carboxy uorescein (N3-dsDNA-FAM) were speci cally conjugated with the butadiyne groups of GDY NSs through click chemistry in the presence of Cu2+ and sodium ascorbate (SA), resulting stable ve-membered triazole rings formation, denoted as triazole
As shown in X-ray photoelectron spectroscopy (XPS) survey spectra (Fig. 2D), the peaks at 398.5 eV were corresponding to the N1s of triazoleGDY and N3-dsDNA-FAM, respectively
Summary
A novel sensing platform for sensitive detection of copper(II) ions (Cu2+) in living cells and body fluids was developed by taking advantage of the excellent fluorescence quenching ability of graphdiyne (GDY) and the high specificity of click chemistry for the first time. By taking advantages of the excellent uorescence quenching ability of GDY and the high speci city of click chemistry, we proposed an approach for accurate and sensitive Cu2+ detection in the present study.
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