Abstract

In this paper we consider graph traversal problems that arise from a particular technology for DNA sequencing — sequencing by hybridization (SBH). We first explain the connection of the graph problems to SBH and then focus on the traversal problems. We describe a practical polynomial time solution to the Travelling Salesman Problem in a rich class of directed graphs (including edge weighted binary de Bruijn graphs), and provide a bounded-error approximation algorithm for the maximum weight TSP in a superset of those directed graphs. We also establish the existence of a matroid structure defined on the set of Euler and Hamilton paths in the restricted class of graphs.KeywordsMinimum Span TreeTravelling Salesman ProblemHamilton PathBinary NumberBasic CircleThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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