Graph Theory-Based Approach in Brain Connectivity Modeling and Alzheimer's Disease Detection.

Abstract

There is strong evidence that the pathological findings of Alzheimer's disease (AD), consisting of accumulated amyloid plaques and neurofibrillary tangles, could spread around the brain through synapses and neural connections of neighboring brain sections. Graph theory is a helpful tool in depicting the complex human brain divided into various regions of interest (ROIs) and the connections among them. Thus, applying graph theory-based models in the study of brain connectivity comes natural in the study of AD propagation mechanisms. Moreover, graph theory-based computational approaches have been lately applied in order to boost data-driven analysis, extract model measures and robustness-effectiveness indexes, and provide insights on casual interactions between regions of interest (ROI), as imposed by the models' architecture.