Abstract
Introduction: Grape seed extract (vitis vinifera) contains antioxidant compounds with ability to prevent aluminium chloride induced hepatotoxicity. Aims & Objectives: To study the effects of grape seed extract on body weight, liver weight and relative tissue weight index in aluminium chloride treated rats. Place and Duration of Study: This experimental study study was conducted at the Animal House of Post Graduate Medical Institute, Lahore. Duration of study was February 2017 to February 2018. Material & Methods: 24 adult, healthy albino rats (male) were divided in to three groups. Group A was given distilled water by gavage (1ml/day), Group B was given aluminium chloride (34mg/kg body weight) and group C was given aluminium chloride plus grape seed extract (34mg/kg and 200 mg/kg body weight) by gavage. Whole treatment continued for 42 days. Statistical Package for Social Sciences (SPSS) version 21 was used for entering and analyzing data.p value of ? 0.05 was considered significant. Results: A significant difference in body weights of Group B and C rats was noted at the end of the study. Mean liver weight was significantly reduced in aluminium treated group and near normal restoration of liver weight was seen in group C receiving grape seed extract. Conclusion: Excessive aluminium chloride exposure led to a reduction in body weight, and liver weight. Grape seed extract being an antioxidant improved these effects.
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