Granulomatous meningoencephalomyelitis in dogs: A review.

Emma J O'Neill,Darren Merrett,Boyd Jones

doi:10.1186/2046-0481-58-2-86

Emma J O'Neill, Darren Merrett + Show 1 more

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https://doi.org/10.1186/2046-0481-58-2-86

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Abstract

Granulomatous meningoencephalomyelitis (GME) is an inflammatory disease of the central nervous system in dogs that is characterised by focal or disseminated granulomatous lesions within the brain and/or spinal cord, non-suppurative meningitis and perivascular mononuclear cuffing. The aetiology of the disease remains unknown, although an immune-mediated cause is suspected. This article reviewed the typical history, clinical signs and pathology of the condition along with current opinions on pathogenesis. The potential differential diagnoses for the disease were discussed along with current treatment options.

Highlights

Granulomatous meningoencephalomyelitis (GME) is an idiopathic inflammatory condition of the central nervous system (CNS) in dogs that was first reported by Braund and colleagues in 1978
Pathology Histologically, GME lesions occur predominantly within the white matter of the CNS, characterised by dense aggregates of inflammatory cells arranged in whorling patterns around blood vessels
TABLE 2b: The frequency of clinical signs described in 151 GME cases reported in the literature disseminated forms has more recently been challenged by Demierre et al (2001) who found that the disease course was not correlated with the size of lesions but rather with the extent of mast cell infiltration

Summary

Introduction

Granulomatous meningoencephalomyelitis (GME) is an idiopathic inflammatory condition of the central nervous system (CNS) in dogs that was first reported by Braund and colleagues in 1978. Three forms of GME have been described, based primarily on the presenting clinical signs, namely: focal, disseminated (multifocal) and ocular (Braund, 1985; Sorjonen, 1987a).

Results

Conclusion