Abstract
A 31-year-old woman was referred with a painful mass in the left breast that was initially treated with antibiotics. Three weeks later, the mass had increased and polyarthritis and erythema nodosum had developed in both legs. A core needle biopsy led to a diagnosis of granulomatous mastitis with arthritis and erythema nodosum. Low-dose prednisolone (10 mg) rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only nine patients with granulomatous mastitis with erythema nodosum have been described. We reviewed the literature to determine the clinicopathological features and treatment of granulomatous mastitis. Appropriate diagnosis and steroid therapy should result in excellent outcomes.
Highlights
Granulomatous mastitis is a very rare, chronic inflammatory disease of the breast that is often difficult to distinguish from breast cancer
How to cite this paper: Noma, M., Masahiro, O., Matsuura, K. and Itamoto, T. (2014) Granulomatous Mastitis with Erythema Nodosum That Responded to Low-Dose Steroid: Case Report and Literature Review of Nine Patients
We describe granulomatous mastitis associated with erythema nodosum and arthritis that responded to low-dose steroid therapy
Summary
Granulomatous mastitis is a very rare, chronic inflammatory disease of the breast that is often difficult to distinguish from breast cancer. The underlying cause remains unknown, the histological findings and responsiveness to steroid therapy suggest that the disease is immune-mediated. Adams et al first reported during 1987 that patients with granulomatous mastitis can occasionally develop systemic symptoms such as erythema nodosum [1]. How to cite this paper: Noma, M., Masahiro, O., Matsuura, K. and Itamoto, T. (2014) Granulomatous Mastitis with Erythema Nodosum That Responded to Low-Dose Steroid: Case Report and Literature Review of Nine Patients. M. Noma et al Nine patients have been described since including the present patient. We describe granulomatous mastitis associated with erythema nodosum and arthritis that responded to low-dose steroid therapy. We reviewed the literature and discuss the clinicopathological features and treatment of this disease
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