Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis

Peggy Perrin,Jérome Olagne,Arnaud Delbello,Stanislas Bataille,Laurent Mesnard,Claire Borni,Bruno Moulin,Sophie Caillard

doi:10.1016/j.ekir.2021.11.020

Abstract

Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis

Highlights

Primary hyperoxalurias (PHs) are rare genetic disorders that cause hyperproduction of oxalate in the liver
Histology examination revealed the presence of reactive granulomas consisting of both multinucleate giant cells and macrophages that typically surrounded Ca-Ox crystals (Supplementary Figure S3)
Recurrence of nephropathy leads to early renal failure after the first kidney transplantation in patients #4 and #3.6

Summary

Introduction

Primary hyperoxalurias (PHs) are rare genetic disorders that cause hyperproduction of oxalate in the liver. #, number; Ca-Ox, calcium-oxalate; DGF, delayed graft function; DVT, deep vein thrombosis; ESRD, end-stage renal disease; F, female; KT, kidney transplantation; LT, liver transplantation; LKT, liver–kidney transplantation; M, male; NA, not available; PH, primary hyperoxaluria; SLKT, simultaneous liver–kidney transplantation. A biopsy of a hypermetabolic vertebral lesion in patient #1 revealed the presence of an inflammatory granulomatous reaction elicited by Ca-Ox crystals (Supplementary Figure S2, panels K–O).

Results

Conclusion