Abstract
Lymphocytic or granulomatous hypophysitis is a rare entity with a difficult diagnosis. Our objective was to report a patient with non-tuberculous granulomatous hypophysitis. An HIV-negative 45-year old man with confusional state, subacute ophthalmoplegia, and clinical and laboratory findings of panhypopituitarism was seen in the emergency unit. A cranial MRI showed a sellar mass suggestive of hypophysitis. After an unsuccessful attempt with steroids and antituberculous drugs the patient died. Post-mortem histopathology revealed granulomatous lesions and restriction fragment length polymorphism analysis confirmed the presence of Mycobacterium gordonae’s DNA. In conclusion, we should consider granulomatous hypophysitis in the differential diagnosis of non-secreting hypophyseal tumors. The etiology of a pituitary granuloma by a non-tuberculous mycobacteria is best reached by histopathological techniques and molecular assays. The optimal therapy is yet to be established.
Highlights
The pituitary region is susceptible to involvement by cystic, neoplastic, infectious [Neurology International 2009; 1:e18] [page 63]day 11 of hospitilization
Lar reaction suggestive of mycobacterial dis- The other[2] reported cases of GH due to nonease was observed; Ziehl-Neelsen, tuberculous mycobacteria with no history of modified Kinyoun and Auramine-Rodamine immunosupression included a 32-year-old staining of the specimen did not identify any woman who presented with fever, headaches, References acid-fast bacteria (AFB)
(RFLP) analysis originally described by Roth et intrasellar mass of heterogeneous appearance
Summary
The pituitary region is susceptible to involvement by cystic, neoplastic, infectious [Neurology International 2009; 1:e18] [page 63]day 11 of hospitilization. The autopsy showed tious material.[8] In our patient, the critical sys- is best reached by histopathological techan enlarged, fibrous and thickened pituitary temic and neurological condition made this niques and molecular assays. Lar reaction suggestive of mycobacterial dis- The other[2] reported cases of GH due to nonease was observed; Ziehl-Neelsen, tuberculous mycobacteria with no history of modified Kinyoun and Auramine-Rodamine immunosupression included a 32-year-old staining of the specimen did not identify any woman who presented with fever, headaches, References acid-fast bacteria (AFB).
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