Abstract
Cutaneous granulomatous reaction is an immune response in which epithelioid histiocytes and other inflammatory cells are seen. Noninfectious granulomatous diseases of the skin encompass a broad group. Those of systemic diseases including sarcoidosis, Blau syndrome, Crohn disease, and chronic granulomatous disease would have different prognosis. Localized processes include Melkersson-Rosenthal syndrome and granulomatous rosacea. A number of reactive conditions yet have implication for systemic diseases are granuloma annulare, rheumatoid nodule, necrobiosis lipoidica, necrobiotic xanthogranuloma, and palisaded neutrophilic and granulomatous dermatitis. In addition to granulomatous reaction, cutaneous eruptions associated with underlying endocrine abnormalities including scleromyxedema, pretibial myxedema, and bullous diabeticorum; systemic amyloidosis; and a number of nutritional deficiencies such as pellagra in niacin or vitamin B3 deficiency, acrodermatitis enteropathica and necrolytic migratory erythema in zinc deficiency, phrynoderma in vitamin A, and scurvy in vitamin C deficiency will be discussed in this chapter.
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