Abstract
The term refers to an extramedullary collection of immature myeloid cells; rarely, it may precede peripheral blood or bone marrow involvement, presenting as a diagnostic challenge. The present communication deals with four cases of granulocytic sarcoma. Fine needle aspiration cytology (FNAC) was performed for all the cases and a diagnosis of granulocytic sarcoma was suspected. Subsequently, a complete blood count was performed which revealed blasts in the peripheral blood and a diagnosis of acute myeloid leukemia (AML) was confirmed on bone marrow examination. Here, we emphasize the utility of FNAC for making the correct diagnosis of this entity in cases where AML was previously not suspected. DOI:10.21276/APALM.1587
Highlights
Granulocytic sarcoma (GS) or myeloid sarcoma is a tumoral lesion which consists of immature cells of granulocytic series
The term chloroma was assigned to this condition due to its green colour attributed to the enzyme myeloperoxidase (MPO).It has been identified as an extramedullary presentation of acute leukemias especially in acute myeloid leukemia
Granulocytic sarcoma can occur in a variety of locations throughout the body with no predilection for a specific organ, [2] in the cases reported here no specific pattern of organ involvement was observed.GS is a rare manifestation of acute myeloid leukemia (AML) which usually arises during or after the course of the disease, about 8% of patients are diagnosed on autopsy
Summary
Granulocytic sarcoma (GS) or myeloid sarcoma is a tumoral lesion which consists of immature cells of granulocytic series. The term chloroma was assigned to this condition due to its green colour attributed to the enzyme myeloperoxidase (MPO).It has been identified as an extramedullary presentation of acute leukemias especially in acute myeloid leukemia Less commonly, it has been observed during the course of myelodysplastic syndrome, chronic myeloid leukemia and other myeloproliferative diseases. Case 2: A 30 years old lady with multiple swellings in neck since 15 days with fever Her CBC revealed marked leucocytosis with left shift and basophilia. He was diagnosed as AML-M4 on bone marrow aspiration examination. Case 4: A 39 year lady with a left side neck swelling of 20 days duration She was anemic with Hb- 3.4gm% and peripheral blood examination showed 55% blasts. Basophils Bands Metamyelocytes Myelocytes Promyelocytes Blasts Bone marrow aspiration report
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