Abstract
Abstract : The experiment was designed to test the hypothesis that, in hypertransfused dogs with suppressed erythropoiesis, endotoxin-induced increased muelopoietic stimulation 24 hours after irradiation would enhance leukocytic recovery. The treatment combination of transfusion polycythemia and endotoxin was compared to a control group receiving no therapy or to the results obtained from groups of dogs receiving each treatment alone. The radiation exposure was 150 rads of total body x rays. An accentuated abortive rise in the group receiving the combined treatment, accelerated recovery in both groups receiving endotixin, and impaired leukocytic recovery in the polycythemic animals were observed. Accentuated depression of platelets and splenic enlargement inversely correlated with the platelet levels were observed in the animals receiving transfusion therapy regardless of whether they received endotoxin. It is felt that the data support the concept of interdependence between the various cell lines of hematopoiesis in an experimental model not previously described.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
