Granulocytes function in patients with chronic venous insufficiency followed by chronic wounds

Abstract

To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency. There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed. De Sole method was used to analyze chemiluminescent and spontaneous activity of neutrophils of peripheral blood. Advanced generation of active forms of oxygen was revealed in patients with chronic wounds and chronic venous insufficiency. Complex ozone therapy including intravenous administration of ozonized autologous blood, oxygen-ozone and ultrasonic exposure of the wound and cryogenic stimulation reduce painful period up to 3.1±0.6 days, accelerate epithelialization of the wound and normalize release of active forms of oxygen.