Abstract
Thirty infants and children with various diseases and 19 controls were given intravenous injections of a purified bacterial endotoxin to study their bone marrow granulocyte reserves. No serious reactions or sequellae were seen with the dosages employed. A significant increase in circulating granulocytes was observed in all hematologically normal children. The range and nature of the responses were compared to children with various diseases. Poor-to-absent granulocytic responses were seen in children with aplastic anemia and acute leukemia. With certain recognized limitations in interpretation, the test would appear to be a safe and useful adjunct for the study of marrow function in children.
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