Abstract
the relatively huge dose of amethopterin that is given to these children. Is it recovered? What part of it is excreted at what rate in the urine or in the stools? I t seems to me that one might expect rather severe results in the mucosa of the gastrointestinal tract from such a relatively huge single dose, but such changes were evidently not seen. Therefore I wonder how much of this dose is actually retained. J. PERmN, CINCINNATI. Dr. Condit has written several papers on this and done many studies. The drug is not excreted in toto for several weeks or months after these doses. There is a certain amount, in most instances a large amount, which is bound in the body tissues. However, after doses as high as 16 mg. per kilogram every 2 weeks, Condit found that the bone marrow recovered and that normal levels of folic acid were excreted in the urine in 2 or 3 days. In other words, the normal tissues and normal cells escape the enzyme block more readily than do the rapidly metabolizing leukemic cells.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
