Granulocyte-colony stimulating factor-producing squamous cell carcinoma arising in ovarian mature cystic teratoma: A case report

Satoshi Ichigo,Atsushi Imai,Kazutoshi Matsunami,Hiroshi Takagi,Takayuki Murase,Tsuneko Ikeda

doi:10.4236/ojog.2013.39126

Satoshi Ichigo, Atsushi Imai + Show 4 more

Open Access

https://doi.org/10.4236/ojog.2013.39126

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Abstract

Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features are not well known because of the small number or reported cases. We report G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma. An 80-year-old woman underwent suboptimal surgical excision of stage IIIC ovarian cancer. Prior to the treatment, the patient presented severe granulocytosis and elevated serum G-CSF concentration. With the help of histopathological and immunohistochemical studies, we diagnosed this case to be a poorly differentiated squamous cell carcinoma developed in ovarian mature cystic teratoma, which highly expressed G-CSF. During radiation therapy, the patient died from rapid growth of residual tumor and peritoneal dissemination 2 months after surgery. This is the first case of G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma, and its prognosis was very poor.

Highlights

We report Granulocyte-colony stimulating factor (G-CSF)-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma
Our case met all the criteria, confirming that the patient presented with G-CSF-producing ovarian cancer
Tachibana et al showed that G-CSF production by transitional cell carcinoma of the bladder augments autocrine growth, which may in part explain the poor prognosis [12]

Summary

INTRODUCTION

*Conflict of interest: The authors have no conflict of interest to disclose. #Corresponding author. Ducing tumor arises from various organs (e.g. lung, stomach, esophagus, gall bladder, thyroid, urinary bladder, liver, uterine cervix, colon) [1,2,3,4,5,6]. This type of tumor produces various cytokines including G-CSF, and induces severe granulocytosis as a paraneoplastic syndrome. Because of its very poor prognosis, it appears justified to report an additional and rather unusual case of G-CSF-producing ovarian cancer, and to focus some attention on this type of neoplasm

CASE REPORT

Findings

DISCUSSION