Granulocyte Colony-Stimulating Factor (G-CSF) Induced Aortitis: A Case Report with Literature Review

Abstract

Granulocyte colony-stimulating factor (G-CSF) is widely used as a neutrophil supportive therapy in cancer chemotherapy. Recently, some cases of G-CSF-induced aortitis are reported. Our case patient is a 54-year-old female diagnosed with breast cancer and received adjuvant chemotherapy with prophylactic use of G-CSF. She developed G-CSF-induced aortitis 20 days after the use of G-CSF. The disease was diagnosed with serum markers and radiologic findings. Her symptoms and imaging findings were rapidly improved with high-dose steroid therapy. The rapid improvement of the disease implies that prompt diagnosis with treatment can prevent severe vascular complications.