Granular cell tumour – Adenocarcinoma collision tumour of the oesophagus: A case report

Abstract

We report a case of an unusual oesophageal collision tumour composed of granular cell tumour and adenocarcinoma in a 68-year-old woman. The patient had a history of Barrett's oesophagus and hiatus hernia. A 17 mm distal oesophageal nodule was discovered on endoscopic surveillance. Histologically, the excised nodule comprised an invasive 3mm well-differentiated intramucosal adenocarcinoma which showed permeation of an adjacent 1.8mm granular cell tumour and extended to a radial margin focally. The adenocarcinoma was arising in a background of Barrett's oesophagus with high-grade dysplasia. The patient was followed up closely with multiple endoscopic procedures and biopsies. The patient had no signs of recurrence 5 years after the initial diagnosis. To date, only one such collision tumour has been reported in English literature. We report a case of an unusual oesophageal collision tumour composed of granular cell tumour and adenocarcinoma in a 68-year-old woman. The patient had a history of Barrett's oesophagus and hiatus hernia. A 17 mm distal oesophageal nodule was discovered on endoscopic surveillance. Histologically, the excised nodule comprised an invasive 3mm well-differentiated intramucosal adenocarcinoma which showed permeation of an adjacent 1.8mm granular cell tumour and extended to a radial margin focally. The adenocarcinoma was arising in a background of Barrett's oesophagus with high-grade dysplasia. The patient was followed up closely with multiple endoscopic procedures and biopsies. The patient had no signs of recurrence 5 years after the initial diagnosis. To date, only one such collision tumour has been reported in English literature.