Granular Cell Tumor of Suggesting Carcinoma: Case Report

Abstract

The granular cell tumor, also called Abrikossof tumor or granular cell myoblastoma is a rare benign tumor found in several locations. Approximately 5% of cases occur in the breast and is related to breast cancer of 1: 1000. The histogenesis of the tumor is uncertain. It is believed that its appearance is the result of the altered metabolism of Schwann cells, this being reinforced by the presence of S-100 protein immunohistochemical. In breast cancer, the tumor occurs in both sexes, between 30 and 50 years, focusing equally on both breasts, being more common in superior medial quadrant (course of the supraclavicular nerve). Clinically, granular cell tumor presents as nodules poorly demarcated, painless, and sizes ranging from 0.5 to 3 cm and may occur in the deep portion of the mammary tissue, leading to fixation to the pectoral muscle, and thus causing shrinkage nipple and skin, mimicking malignancy. Its differential diagnosis is made with apocrine carcinoma and a mammogram and ultrasound are not useful for differentiation with cancer. The granular cell tumor has a good prognosis, most commonly treated with surgical excision of the lesion with clear margins, and may recur in 15% if excision is incomplete. CASE REPORT: CSP, 23, female, single, nuligesta, Catholic, born and raised in Bahia, without comorbidities and without any personal and / or family history of breast pathologies. Complained - is the appearance of a nodule in the left breast for 3 months of rapid growth and painless. On physical examination, breast medium volume, symmetrical, with a 1.5 cm nodule, painless, hard, mobile, located in the inferomedial quadrant of left breast with no axillary lymph node. Performed breast ultrasound showing a nodule at the junction of the medial quadrants of the left breast of 1.1 x 0. 9 x 1.0 cm with irregular borders and mammography nodule with spiculated margins to 13 mm in the inferomedial quadrant, with limits bad defined. Patient brought fine needle aspiration done at another facility, with results suggestive of breast carcinoma. In Hospital Pearl Byington-core biopsy was performed, indicating granular tumor cells suggested by the presence of protein S-100 in imunohitoquimica. The patient underwent tumor excision with margins, and the diagnosis confirmed in paraffin. Currently, the patient is under regular follow-up this facility, with no recurrence for 9 months.