Granular Cell Tumor of Esophagus: A Rare Disease of the Esophagus

Hiang Jin Tan,Cheryl Xi Zi Chong,Hock Soo Ong,Kok Hing Lim

doi:10.24983/scitemed.acri.2018.00076

Hiang Jin Tan, Cheryl Xi Zi Chong + Show 2 more

Open Access

https://doi.org/10.24983/scitemed.acri.2018.00076

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Abstract

Esophageal granular cell tumors (GCT) represent a rare entity of tumors of the esophagus. Patients with esophageal GCTs are usually asymptomatic, with the lesion most commonly presenting as an incidental finding on endoscopy. The GCTs of the esophagus are poorly understood in medical literature. It is unknown if they undergo malignant degeneration, whether the malignancy can be diagnosed preoperatively, and how the tumor can be managed. The authors evaluated the clinical and pathologic features of all esophageal GCTs at their institution to understand them better.

Highlights

Granular cell tumors (GCT) are uncommon, benign soft tissue neoplasms originating from Schwann cells
GCTs were first reported by Abrikossoff in a case series composed of benign tumors that were removed from the tongue, and according to medical literature, they could be found in other sites of the body as well [1]
We report a case series of 4 patients diagnosed with GCT of the esophagus in our institution to further understand the clinical and pathological characteristics of these tumors and discuss on their follow-up and management

Summary

Introduction

Granular cell tumors (GCT) are uncommon, benign soft tissue neoplasms originating from Schwann cells. Lesional cells were positive for S100, PAS, and CD 68 She had a repeated endoscopy performed the following year, which revealed similar histology. EGD performed revealed an esophageal submucosal lesion where histology returned as granular cell tumor. EGD performed revealed a mid-esophageal submucosal lesion, 25 cm from incisors, where histology returned as GTC. EGD revealed a 3 mm nodule located at 28 cm from incisors, with the histology returned as GCT (Figure 2) She underwent an EUS, which revealed a lesion arising from the mucosa without extension into the surrounding structures (Figure 3). She had endoscopic mucosal resection performed with histology returned as granular cell tumor of 3 mm in size with clear margins.

Findings

Discussion

Conclusion