Abstract
Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.
Highlights
Dermatofibroma is a commonly occurring cutaneous entity usually centered within the dermis
Dermatofibromas are referred to as benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytomas
Benign fibrous histiocytoma is considered as one of the most common benign tumors Benign fibrous histiocytoma is considered as one of the most common benign tumors of the skin, with a very low recurrence rate ranging from 3% to 5% [5]
Summary
Dermatofibroma is a commonly occurring cutaneous entity usually centered within the dermis. Dermatofibromas are referred to as benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytomas These mesenchymal cell lesions of the dermis clinically are firm subcutaneous nodules which occur on the extremities in the vast majority of cases and which may or may not be associated with overlying skin changes [1,2]. The features of the variants may represent the predominant component of the lesion, making the identification of the histiocytoma more difficult [4]. Correct identification of these variants is important to avoid misdiagnosis of a possibly aggressive lesion.
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