Abstract
(J Clin Anesth. 2021;75:110469. [Epub July 24, 2021]) 5-HT3 receptor antagonists have received attention as a possible intervention for preventing spinal-anesthesia induced hypotension during cesarean section, which occurs in 55% to 100% of cases. The Bezold-Jarisch reflex (BJR) appears to govern this adverse response to spinal anesthesia and includes symptoms of hypotension, apnea, and bradycardia. These effects have been shown to be prevented by the use of 5-HT3 antagonists including ondansetron and granisetron. This prospective, double-blinded, randomized placebo-controlled trial tests the efficacy of high-dose administration of these drugs to prevent spinal anesthesia-induced hypotension in elective cesarean section.
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