Grand challenges in bone endocrinology.

Jon Tobias

doi:10.3389/fendo.2010.00008

Abstract

Grand challenges in bone endocrinology.

Highlights

A related question is whether bone metabolism is related to energy metabolism as a consequence of interactions with insulin, and whether there is significant interplay with endocrine pathways originating from the intestine
Further recent work by Karsenty and colleagues suggests that gut-derived hormones exert a profound influence on bone mass, based on their findings in transgenic mice which suggest that reduced production of serotonin by the gut underlies familial high bone mass in patients with mutations of the LRP5 gene (Yadav et al, 2008), which in turn suggests that serotonin antagonists represent a novel approach to treating osteoporosis (Yadav et al, 2010)
Several paracrine factors have being identified which are involved in the local actions of PTH on bone, such as the RANK/RANKL/OPG system involved in regulating osteoclast differentiation, and sclerostin which has been implicated in PTH-dependent effects on the osteoblast lineage (Kramer et al, 2010)

Summary

Introduction

A related question is whether bone metabolism is related to energy metabolism as a consequence of interactions with insulin, and whether there is significant interplay with endocrine pathways originating from the intestine. Dissecting out the mechanism of action of PTH, the major endocrine regulator of calcium metabolism, is a further important challenge. Several paracrine factors have being identified which are involved in the local actions of PTH on bone, such as the RANK/RANKL/OPG system involved in regulating osteoclast differentiation, and sclerostin which has been implicated in PTH-dependent effects on the osteoblast lineage (Kramer et al, 2010).

Results

Conclusion