Abstract
Conventional methods for diagnosing CRBSI such as quantitative or semiquantitative catheter-tip cultures require removal of the CVC. However, CVCs removed on suspicion of CRBSI prove to be the source of blood stream infection in only 15% of cases. 1 Bong J.J. Kite P. Ammori B.J. Wilcox M.H. McMahon M.J. The use of a rapid in situ test in the detection of central venous catheter-related bloodstream infection: a prospective study. J Parenter Enteral Nutr. 2003; 27: 146-150 Crossref PubMed Scopus (25) Google Scholar It has been shown that clinically suspected CRBSI can be detected by the differential time to positivity (DTP) method or Gram/acridine-orange leukocyte cytospin (AOLC) test without catheter removal. 2 Chen W.T. Liu T.M. Wu S.H. Tan T.D. Tseng H.C. Shih C.C. Improving diagnosis of central venous catheter-related bloodstream infection by using differential time to positivity as a hospital-wide approach at a cancer hospital. J Infect. 2009; 59: 317-323 Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar , 3 Kite P. Dobbins B.M. Wilcox M.H. McMahon M.J. Rapid diagnosis of central-venous-catheter-related bloodstream infection without catheter removal. Lancet. 1999; 354: 1504-1507 Abstract Full Text Full Text PDF PubMed Scopus (144) Google Scholar Whether microorganisms can be detected in blood drawn from CVCs before symptoms of CRBSI become manifest using the Gram/AOLC method has not been investigated. The aim of this prospective pilot study was to investigate whether the Gram stain/AOLC method might be a potentially useful way to anticipate the diagnosis of CRBSI.
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