Abstract
Strigolactones (SLs) are a group of plant hormones exuded in the plant rhizosphere. They act as a signaling role regulating essential stages of plant development. Carlactonic acid (CLA) is a non-canonical SL and an essential intermediate for the biosynthesis of other SLs. In this paper, we reported the gram-scale synthesis of CLA and its enantiomer. To obtain enantiopure CLA, we separated the C11-enantiomeric intermediates by a chemical resolution with (R)-/(S)-phenylethylamine. Our synthesis employed inexpensive starting materials, moderate reaction conditions, and chiral resolution, thus enabling the synthesis of CLA in gram scale. Our research lays the foundation for the future chemoenzymatic synthesis of SLs.
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