Abstract
➢ Gustilo-Anderson type-III open fractures remain a considerable cause of morbidity and amputation.➢ Systemic antibiotic prophylaxis with cephalosporins was introduced in the 1970s and substantially reduced the prevalence of infectious complications following injury.➢ The use of antibiotics with an extended gram-negative (EGN) spectrum, such as aminoglycosides, is controversial; however, they are commonly used in type-III open fractures.➢ Emerging literature has suggested that EGN antibiotic prophylaxis for type-III open fractures may not reduce infectious complication rates.➢ Reducing the routine use of EGN antibiotics may be an important component of antimicrobial stewardship in orthopaedic trauma to reduce bacterial resistance and thus more complicated infections.
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Schedule a callMore From: The Journal of bone and joint surgery. American volume
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