Abstract
inflammatory cells, collagen deposition and expansion of airways in the lung despite showing no sign of acute illness or weight loss. Masson’s trichrome revealed increased fibrosis in the lung (Figure 2), but not in other organs. Conclusion: We have shown that in the NSG mouse, a combination of Cy/TBI with a lownumber of G-CSFmobilized human PBMCs causes chronic lung inflammation and fibrosis that can serve as an important pre-clinic model of lung cGVHD.
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