Graft vasculopathy in upper extremity allotransplantation: Results of a retrospective high-resolution ultrasonographic study.

Abstract

Graft vasculopathy (GV) is the most severe pathologic change of chronic rejection in vascularized composite allotransplantation. Since 2012, the intimal media thickness (IMT) of radial and ulnar arteries was annually monitored by high-resolution ultrasonography in seven bilateral upper extremity transplant (UET) patients. We also investigated the IMT of seven matched healthy subjects (controls). No significant difference between IMT values of controls and UET patients was found. The median IMT values of recipient radial and ulnar arteries were 0.23mm and 0.25mm, respectively, while the median IMT values of grafted radial and ulnar arteries were 0.27mm and 0.30mm, respectively. There was a statistically significant difference in the IMT values of the grafted and recipient ulnar arteries (p=.043), but this difference was no longer significant when patient #2 was excluded. He showed a significant difference between recipient and grafted arteries and significantly higher IMT values (p=.001) of his grafted arteries compared with those of all transplanted patients. This patient developed GV leading to graft loss 11years after the transplantation. In conclusion, this study showed a significant IMT increase in an UET recipient who developed GV.