Abstract
As Magnetic Resonance Spectroscopy is one of the most powerful methods to obtain a non-invasive view of brain metabolism we, as others, judge it a promising tool for tumor grading. We investigated 8 patients harbouring astrocytomas (histologically confirmed via stereotactic serial biopsy) of different malignity with single voxel (PRESS) 1 H MRS techniques. The measurements were also repeated after interstitial radiosurgery using 125 Iodine, when this treatment modality was deemed indicated.Apart from the decrease of NAA (N-acetyl-L-aspartate), the tumor spectra show the presence of lactate (Lac) which however does not correlate to the tumor grade. More interesting for this and confirmed in our initial trial is the fact that choline (Cho) varies from almost normal concentrations in low-grade astrocytomas to a fourfould increase in the high-grade lesions with strong correlation to the tumor malignity. After stereotactic radiosurgical treatment, a decrease of the previously increased choline signal is observed. The reduction of choline seems to be dose related.
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