Abstract
Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office-based laryngoscopy examination is presented. An optical-ballast-based 4f optical relay system is proposed to realize variable working distance with a constant optical delay. In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis.
Highlights
Laryngeal carcinoma is one of the most common primary head and neck malignancies
For the 1310-nm wavelength, which is the center wavelength of the Optical coherence tomography (OCT) light source, the GRIN lens is close to one pitch but cannot be considered as an ideal optical relay anymore, especially when the average working distance of the probe reaches about 65 mm for laryngeal imaging
The flexible approach has the advantages of a fixed working distance, physicians can handle the device easier
Summary
Laryngeal carcinoma is one of the most common primary head and neck malignancies. Despite significant advances in cancer treatment, early detection of a malignant lesion and its curable precursors is paramount to ensure successful treatment and patient survival. Title Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx
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