GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine

Mert Döşkaya,Mina Kalantari-Dehaghi,Craig M Walsh,Elżbieta Hiszczyńska-Sawicka,D Huw Davies,Philip L Felgner,Liza S.Z Larsen,Richard H Lathrop,G Wesley Hatfield,Jessica R Schulz,Yüksel Gürüz,Frances Jurnak

doi:10.1016/j.vaccine.2006.10.060

GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine

Mert Döşkaya, Mina Kalantari-Dehaghi + Show 10 more

Open Access

https://doi.org/10.1016/j.vaccine.2006.10.060

Copy DOI

Journal: Vaccine	Publication Date: Nov 20, 2006
Citations: 57

Affiliation: University of California, Irvine, Ege University, Gdańsk University of Technology

#Codon-optimized DNA #Recombinant Protein Vaccine + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-optimized GRA1 DNA vaccine was slightly better than wild type GRA1 DNA vaccine.

Full Text