Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormonal systems at various levels, resulting in adverse health effects. EDCs belong to diverse chemical families and can accumulate in the environment, diet and body fluids, with different levels of persistence. Their action can be mediated by several receptors, including members of the nuclear receptor family, such as estrogen and androgen receptors. The G protein-coupled estrogen receptor (GPER), a seven-transmembrane domain receptor, has also attracted attention as a potential target of EDCs. This review summarizes our current knowledge concerning GPER as a mediator of EDCs' effects.
Highlights
Reviewed by: Peter Thomas, University of Texas at Austin, United States Alain Couvineau, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormonal systems at various levels, resulting in adverse health effects
This review summarizes our current knowledge concerning G protein-coupled estrogen receptor (GPER) as a mediator of endocrine-disrupting chemicals (EDCs)’ effects
Summary
Reviewed by: Peter Thomas, University of Texas at Austin, United States Alain Couvineau, Institut National de la Santé et de la Recherche Médicale (INSERM), France. GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs). GPER is required for the effect of aldosterone mediated by the mineralocorticoid receptor (MR) in breast cancer cell lines [16].
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